dr Miloš ŽivkovićMedically reviewed by: dr Miloš Živković — Imedic poliklinika, Beograd.

Updated: 27.10.2026.

Mesotherapy – key facts

  • Areas: face, neck, décolleté, scalp and some body areas
  • Products: cocktails with hyaluronic acid, vitamins, amino acids and peptides
  • Treatment time: 30–60 minutes
  • Recovery: minimal, with mild redness and injection marks
  • Number of treatments: usually a series, planned individually

In short

  • Mesotherapy delivers cocktails of hyaluronic acid, vitamins and peptides into the skin with tiny injections.
  • It does not add volume or lift the face – it improves hydration, freshness and skin quality.
  • We choose the cocktail and number of treatments after assessing the area, skin condition and goal.

Is mesotherapy for the face, neck, and décolletage a regular part of your skincare routine? If so, you’re likely already aware of how mesotherapy can give your skin a radiant and vibrant complexion. If you haven’t experienced this treatment yet, we’re here to address all your questions and uncertainties. By the end of this text, you’ll be able to decide whether to schedule the treatment this week or consider an alternative option.
Aging is an inevitable process that accompanies us throughout our lives. Unfortunately, it can also bring some less aesthetically pleasing changes to our face, neck, and décolletage. The skin becomes tired, wrinkles deepen, and issues such as pigmentation spots, visible capillaries, and other imperfections arise.
However, we bring good news! Experts suggest that genetics only account for 20% of our skin’s appearance, while 80% is within our control. This means that proper care, a healthy lifestyle, a balanced diet, quality sleep, and the right treatments can potentially delay the signs of aging by several years and rejuvenate your skin.
Mesotherapy for the face, neck, and décolletage has been a popular choice among celebrities for many years, and it’s no surprise that it has gained immense popularity in the realm of skincare and rejuvenation. Individuals of different ages, including both women and men, often opt for this treatment, especially when they have important upcoming events where they want to radiate their beauty. Additionally, those who prioritize regular facial care recognize facial mesotherapy as a vital treatment on their yearly calendar to maintain their desired skin look throughout the year.

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What is mesotherapy?

Mesotherapy is a modern aesthetic and anti-aging procedure that involves the injection of mesococktails into the middle layer of the skin using fine needles. This technique deeply hydrates and nourishes the skin with essential ingredients, restoring its vitality, luminosity, and radiance.
Unlike creams and serums used in daily skincare, which primarily target the superficial layers of the skin, mesotherapy penetrates deeper layers. Mesotherapy cocktails consist of various combinations of hyaluronic acid, amino acids, and vitamins. These cocktails not only provide immediate delivery of active ingredients to the skin but also stimulate the production of collagen and elastin. These proteins play a key role in achieving a rejuvenated appearance and maintaining skin elasticity.
The selection of high-quality mesococktails is of utmost importance. For intensive results, a mesococktail with a high concentration of hyaluronic acid, bioactive peptides, vitamin C, and retinol is chosen. Hyaluronic acid, in addition to its remarkable anti-aging effects and intensive hydration, facilitates the gradual release of peptides and vitamins, leading to prolonged regeneration. This approach yields visible rejuvenation even in aged and damaged skin.

“That is why at the consultation we would rather say a treatment is not needed than plan it without a clear goal.”

DOCTOR’S ADVICE · DR MILOŠ ŽIVKOVIĆ

Mesotherapy of the face, hair and body?

Facial mesotherapy is widely recognized as one of the most effective methods for enhancing skin quality. However, its benefits extend beyond the realm of skincare. Mesotherapy is also utilized for addressing hair loss concerns as the mesococktails stimulate new hair growth from follicles and improve the overall quality of existing hair.
When it comes to mesotherapy for the body, it primarily focuses on treating cellulite that may be resistant to improvement through exercise and proper nutrition alone. Even if you have dedicated numerous hours at the gym and made conscious dietary choices, achieving the desired swimsuit body may still prove challenging. In such cases, mesotherapy, in conjunction with other treatments like Alma PrimeX, can provide the final push needed to combat cellulite and attain the desired results. This comprehensive approach not only enhances circulation but also aids in breaking down cellulite and tightening the skin, helping you achieve a more toned and smoother appearance.

mesotherapy face

What does treatment look like?

During the examination, we evaluate the condition and quality of your skin. Based on the analysis, a unique combination of mesococktails is chosen to address your specific skin needs. Prior to the treatment, an anesthetic cream is applied to the cleansed face, neck, or décolleté area to ensure a completely painless experience. Subsequently, mesotherapy cocktails are administered using tiny needles. In our practice, we use Fillmed NCTF 135, Revitacare, and Aesthetic Dermal RSS cocktails.
Recommendation: For mature skin with more pronounced signs of aging, mesotherapy is often combined with other treatments such as lasers, fillers etc.

How long does the treatment take?

A mesotherapy session typically lasts around 60 minutes, and any redness that may occur usually subsides within a few hours.

Is the treatment painful?

Since mesotherapy employs very fine needles and involves the application of an anesthetic cream prior to the procedure, the treatment is generally minimally painful.

Pre-treatment and post-treatment recommendations

On the day of the treatment, it is advised to avoid wearing makeup, engaging in physical activities, swimming, or using a sauna. Additionally, exposure to strong sunlight should be avoided for a few days following the treatment.

How many treatments are needed?

Mesotherapy is one of the treatments that yields visible results within a few days, but the best outcomes are yet to come! It takes several weeks for new collagen to start appearing.
For addressing the initial signs of aging, it is recommended to undergo the first two treatments with a one-month interval, followed by the next two treatments with a two-month interval between them.
In the case of facial mesotherapy for more mature skin, the frequency of treatments is slightly higher. The first two treatments are scheduled with a 15-day interval, while the next two treatments are spaced one month apart. Subsequently, it is necessary to have two additional treatments with a two-month interval between them.
Once the desired results are achieved, mesotherapy should be repeated every three months to provide the skin with a continuous supply of essential bioactive ingredients that help maintain its vitality and youthful appearance.

Mesotherapy mesocotel

What are the results of mesotherapy?

Mesotherapy restores freshness to the skin, reduces the visibility of imperfections, and simultaneously rejuvenates, deeply hydrates, and enhances its radiance. This treatment stimulates collagen and elastin production, resulting in gradual skin tightening and significant improvement in skin quality. In the case of mesotherapy for the body, it reduces the visibility of cellulite, while also promoting skin tightening and smoothness.

Who Is A Candidate For Mesotherapy?

Mesotherapy is a suitable option for:

  • Individuals who desire to refresh their skin.
  • Particularly those with dry and dehydrated skin.
  • Those looking for preventive measures against aging.
  • People who struggle to eliminate cellulite through exercise and diet.

Contraindications

Contraindications for mesotherapy include pregnancy, breastfeeding, blood clotting disorders, autoimmune diseases, active skin infections, and known allergies or hypersensitivity to the ingredients used.
With mesotherapy cocktails, we are unable to treat hyperpigmentation, spots, acne scars, reduce enlarged pores, tighten skin, and eliminate wrinkles. These issues are effectively addressed through treatments such as CO2 laser, laser treatments, chemical peels, and hyaluronic fillers.

Side effects?

Side effects of mesotherapy may include temporary redness, swelling, bruising, tenderness at the injection site, itching, and rare allergic reactions.

Mesotherapy – prices and additional questions?

You can view the price list by clicking on the link. If you have any doubts regarding the mesotherapy feel free to call us at 060/345-0304 or write to us, and we will be happy to address all your questions and concerns.

Mesotherapy or a skin booster?

At the consultation we find out what your skin lacks and only then choose the product.

Book your appointment

Imedic poliklinika is located at Kneza Miloša 23, II sprat, Beograd.

Book your appointment by phone: +381 60 345 0304 or +381 64 237 0707. If you are contacting us from abroad, we are also available on Viber and WhatsApp at the same number.

Medical disclaimer

This page was prepared under the professional supervision of dr Miloš Živković. The information is intended for education and a better understanding of aesthetic procedures, but it cannot replace an individual medical examination, diagnosis or treatment plan. A consultation with a doctor is necessary to assess and choose the right treatment.

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Who we are

Dr Miloš Živković

A doctor in specialist training in aesthetic, plastic and reconstructive surgery at the Faculty of Medicine in Beograd.

Since he began working in aesthetic medicine, he has regularly attended advanced training and courses, so that the techniques he uses follow current knowledge and high professional standards.

His work focuses on hyaluronic fillers, botulinum toxin, skin boosters, collagen stimulators, chemical peels, fractional CO2 laser and scar treatments.

Treatments in this article

Neck and décolleté

Neck and décolleté

We choose neck and décolleté rejuvenation by problem: Botox for vertical bands, fillers and skin boosters for lines and hydration, lasers and Morpheus8 for tone.

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Dark circles

Dark circles

Dark circles are caused by shadow from hollowness, thin lower-eyelid skin or excess pigment. At the consultation we determine the cause and choose the treatment accordingly.

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Tear trough filler

Tear trough filler

Tear trough filler with hyaluronic acid helps with hollow under-eyes – the filler softens the transition between the lower eyelid and cheek and refreshes the look.

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